Metroid: Zero Mission is an action-adventure video game for the Gameboy Advance, developed by Nintendo's R&D1 division and released in 2004. It is a remake of the original 1986 Metroid game, redesigned to feature modernized gameplay, graphics, and a supplementary plotline. The story reiterates the mission of intergalactic bounty hunter Samus Aran, who is sent to the alien-infested planet of Zebes to destroy Mother Brain, the leader of the space pirate force. Focusing on exploration and search for power-ups that enhance Samus's power suit, the game has non-linear gameplay which has influenced the design of many subsequent games known as 'Metroidvania'.

The game was praised for its fluid control scheme, atmospheric music score, and detailed environmental design, being frequently listed among the best games for the GameBoy Advance. Notably, Zero Mission includes a sequence after the original game's finale, where Samus is stripped of her power armour and must escape from a space pirate mothership with limited resources, adding a stealth-based element that was new to the series. This addition along with its informative map system and tutorial-like prologue , not only streamlined the experience for new players of the franchise, but also redefined the gameplay of Metroid, influencing the direction of future entries in the series that follow. Thus, Metroid: Zero Mission stands as a significant title in gaming history, both as a successful remastering of a classic game and as an innovator for the series it belongs to.