Mike Tyson's Punch-Out!! is a boxing video game for the Nintendo Entertainment System (NES) that was released in the year 1987. The game's main character is Little Mac, a budding professional boxer who climbs the ranks of the World Video Boxing Association. The gameplay is unique and quite intricate for its era, focusing more on timing and strategy than fast button pushing. Players are asked to identify opponent's weaknesses, learn patterns, and choose the precise moments to attack or defend. The final challenge of the game is a match against Mike Tyson, a real-world boxer and one of the toughest bosses in gaming history.

The game has been critically praised for its gameplay mechanics, charming 8-bit aesthetic, and it's strategic, rather than brutal approach towards the sport of boxing. Besides being an incredible commercial success, Mike Tyson's Punch-Out!! has had a significant historical impact on the gaming industry. It pioneered the use of patterns and timing in gameplay mechanics and helped define the sports genre on consoles. It is fondly remembered as one of the most iconic games of the 8-bit era and continues to be influential in modern boxing and fighting games.